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Impaired Interleukin-2, Gamma-Interferon Production and Natural Killer Cytotoxicity in Active Systemic Lupus Erythematosus Patients

系統性紅斑性狼瘡病童其第二介白質,丙種幹擾素及自然殺手細胞毒殺能力異常之研究

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摘要


From 1985 to 1987, interleukin-2(IL-2) and gamma-interferon (r-IFN) production and natural killer (NK) cell activity were measured in 10 children suffering from active systemic lupus erythematosus (SLE) before and after steroid and/or immunosuppressive drug treatment. The production of IL-2 and r-IFN was decreased and NK cell cytotoxicity was also suppressed in active lupus patients. After treatment, IL-2 production and NK cell cytotoxicity returned to normal range; r-IFN production also increased, but remained lower than normal.

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並列摘要


From 1985 to 1987, interleukin-2(IL-2) and gamma-interferon (r-IFN) production and natural killer (NK) cell activity were measured in 10 children suffering from active systemic lupus erythematosus (SLE) before and after steroid and/or immunosuppressive drug treatment. The production of IL-2 and r-IFN was decreased and NK cell cytotoxicity was also suppressed in active lupus patients. After treatment, IL-2 production and NK cell cytotoxicity returned to normal range; r-IFN production also increased, but remained lower than normal.

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