豬霍亂沙氏桿菌性肺炎之病理學研究及藥物感受性試驗

Pathologic Studies and Antimicrobial Susceptibility of Salmonella Choleraesuis Pneumonia in Pigs

邱雲棕(Yung-Tsung Chiu) ； 魯懿萍(Yi-Pin Lu) ； 鄭益謙(Ivan-Chen Chang) ； 劉振軒(Chen-Hsuan Liu) ； 陳姿妤(Tzu-Yu Chen)

《中華民國獸醫學會雜誌》 24卷2期 (1998/06) Pp. 99-108

https://doi.org/10.7009/JTCSVS.199806.0099

摘要

自1994年1月至1997年6月從台灣各地，送至本所病理生物系的豬病病例共計2千餘例，以病理診斷配合微生物分離進行病理及病因學確診，分析整理所有病例之最後診斷結果，發現其中有128例經細菌學分離病因鑑定証實為，豬霍亂沙氏桿菌（Slamonella choleraesuis）感染肺炎致死，其中94例為單純感染豬霍亂沙氏桿菌，34例具有併發其他細菌感染，因而以細菌學鑑定為基準，將單純感染豬霍亂沙氏桿菌之肺炎病變進行病理學探討分析。其中病理病變特徵除一般常見的瀰漫性間質性肺炎之外，尚可見以壞死性肺炎、胸膜性肺炎、支氣管性肺炎及肺膿瘍等形式病變出現。組織病理檢查發現，病灶區炎症細胞以組織球、淋巴球和肺泡吞噬細胞浸潤為主，血管和肺泡微血管內常見小血栓混合菌塊的存在，在壞死和膿瘍灶中亦有菌塊的聚集。其它臟器之病變則以脾臟腫大、淋巴結腫大出血、肝壞死、腎臟出血及腦膜炎為主。所分離出的128株豬霍亂沙氏桿菌進行20種藥物感受性試驗，結果發現它對大部份市售藥物均發生抗藥性，只有Florphenicol、Cefotaxime、Enroflpxacine、Ceftiofur的感受性較佳。本報告結果發現，豬霍亂沙氏桿菌並非只形成一般常見的間質性肺炎，尚可造成其他形式較嚴重之肺炎病變。由此可知藥物濫用導至抗藥性新菌的產生，以及更嚴重肺炎變的疫情值得重視。

關鍵字

沙氏桿菌 ； 肺炎 ； 病理學 ； 藥物感受性

並列摘要

From Jan. 1, 1994 to June 31, 1997, 128 cases of Salmonella choleraesuis infection were identified, through bacterial isolation and pathological diagnosis, from over two-thousand cases sent to the Department of Pathobiology, Pig Research Institute, Taiwan. These pigs mainly died from respiratory infection. Among the 128 cases, we found that 94 cases were infected by pure S. choleraesuis and 34 cases were present with secondary bacterial infections Antimicrobial susceptibility of these 128 isolates revealed that they were resisted 16 out of 20 most commonly used drugs. The isolated S. choleraesuis was found susceptible to the florphenicol, cefotaxime, enrofloxacine and ceftiofur with respected to the order of their sensitivity. The pathological findings of these 94 cases were interstitial pneumonia, necrotizing pneumonia, pleuropneumonia, bronchopneumonia and pulmonary abscessation. In the histopathologic examinations of pneumonic specimen, we discovered that the pneumonic lesions are mainly infiltrated by histiocytes, Iymphocytes and alveolar macrophages. The fibrinous microthrombi with bacterial colony were frequently found in the venule and capillary. The necrotic foci and abscess were shown to contain large amount of bacterial colonies. Enlargement of spleen and Iymph nodes, hepatic necrosis, renal hemorrhage and meningitis were also noted. Base on the pathologic findings and the antimicrobial susceptibility tests. Our study suggested that the various pneumonia in the swine could be the result of pure S. choleraesuis infection. It is very probable that the resistant strain of S. choleraesuis could manifested more severe pneumonic lesion.

並列關鍵字

Salmonella choleraesuis ； Pneumonia ； Pathology ； Antimicrobial susceptibility