Evaluation of the Protection Efficacy of Newcastle Disease Vaccination Programs

新城雞病免疫計畫保護效力之評估

蔡向榮(Hsiang-Jung Tsai) ； 林地發(Dih-Fa Lin)

《中華民國獸醫學會雜誌》 25卷1期 (1999/03) Pp. 1-7

https://doi.org/10.7009/JTCSVS.199903.0001

摘要

Various Newcastle disease (ND) vaccination programs were tested for their protection efficacy. In trial 1, SPF chicks were vaccinated with an attenuated or inactivated ND vaccine at 4-day-old, then boosted again with an attenuated or inactivated ND vaccine at 7 days of age or 14 days of age. AII vaccinated groups showed a good protection rate (80-100%) when they were challenged with a virulent ND virus at 5-week-old. In trials 2 and 3, several groups of broilers with high maternal antibodies (geometric mean hemagglutination-inhibition antibody titer was 1:84.5-1:135 at 4-day-old) were simultaneously immunized with an attenuated and an inactivated ND vaccine at 4 days of age , and then revaccinated with an attenuated ND vaccine at 17-day-old. Other groups of broilers were first vaccinated with a live vaccine at 4-day-old, revaccinated with an inactivated vaccine at 14-day-old, and then boosted again with a live vaccine at 17-day-old. Good protection rate (80-100%) was achieved in both groups when they were challenged at 5-week-old. When they were challenged at 3-week-old and 4-week-old, the latter broiler groups had a significantly higher protection rate (100%) than the formal broiler groups (50- 80%) (p ＜ 0.05).

關鍵字

新城雞病 ； 免疫計劃 ； 保護效力

並列摘要

Various Newcastle disease (ND) vaccination programs were tested for their protection efficacy. In trial 1, SPF chicks were vaccinated with an attenuated or inactivated ND vaccine at 4-day-old, then boosted again with an attenuated or inactivated ND vaccine at 7 days of age or 14 days of age. AII vaccinated groups showed a good protection rate (80-100%) when they were challenged with a virulent ND virus at 5-week-old. In trials 2 and 3, several groups of broilers with high maternal antibodies (geometric mean hemagglutination-inhibition antibody titer was 1:84.5-1:135 at 4-day-old) were simultaneously immunized with an attenuated and an inactivated ND vaccine at 4 days of age , and then revaccinated with an attenuated ND vaccine at 17-day-old. Other groups of broilers were first vaccinated with a live vaccine at 4-day-old, revaccinated with an inactivated vaccine at 14-day-old, and then boosted again with a live vaccine at 17-day-old. Good protection rate (80-100%) was achieved in both groups when they were challenged at 5-week-old. When they were challenged at 3-week-old and 4-week-old, the latter broiler groups had a significantly higher protection rate (100%) than the formal broiler groups (50- 80%) (p ＜ 0.05).

並列關鍵字

Newcastle disease (ND) ； Vaccination programs ； Protection efficacy