GABAergic Inhibition and the Effect of Sound Direction on Rate-Intensity Functions of Inferior Collicular Neurons of the Big Brown Bat, Eptesicus Fuscus

GABAergic inhibition shapes many auditory response properties of neurons in the inferior colliculus of the big brown bat, Eptesicus fuscus. This study examined the role of GABAergic inhibition on direction-dependent rate-intensity functions of bat inferior collicular neurons. When plotted at three sound directions (60contralateral, 0and 60ipsilateral relative to recording site), most collicular neurons had nonmonotonic and saturated rate-intensity functions at 60contralateral and 0but had monotonic rate-intensity functions at 60ipsilateral. The dynamic range of rate-intensity functions of majority (＞90%) of collicular neurons significantly decreased as the sound direction changed from 60 contralateral to 60ipsilateral. Bicuculline application increased or decreased the dynamic range of IC neurons in different degrees with sound direction and abolished direction-dependent intensity sensitivity of these IC neurons. Possible mechanisms for these observations are discussed.

並列關鍵字

bat ； bicuculline ； GABAergic inhibition ； inferior colliculus ； rate-intensity function

參考文獻

Aitkin, L. M.,Martin, R. L.(1987).The representation of stimulus azimuth in high best frequency-selective neurons in the central nucleus of the inferior colliculus of the cat.J. Neurophysiol.57,1185-1200.

Google Scholar

Cain, D.,Jen, P. H. S.(1999).The effect of sound direction on frequency tuning in mouse inferior collicular neurons.Chin. J. Physiol.42,1-8.

Google Scholar

Carney, L. H.,Yin, T. C. T.(1989).Responses of low-frequency cells in the inferior colliculus to interaural time differences of clicks: excitatory and inhibitory components.J. Neurophysiol.62,144-161.

Google Scholar

Chen, Y. W.,Tang, K. C.,Jen, P. H. S.(1995).Sound direction affects the frequency tuning, dynamic range and response sensitivity of inferior collicular neurons of the FM bat.Eptesicus fuscus. Soc. Neurosci. Abstr.21,670.

Google Scholar

Erulkar, S. D.(1972).Comparative aspects od spatial localization of sound.Physiol. Rev.52,237-360.

Google Scholar

延伸閱讀

Wu, F. J., & Jen, P. H. S. (2008). GABA-Mediated Modulation of the Discharge Pattern and Rate-Level Function of Two Simultaneously Recorded Neurons in the Inferior Colliculus of the Big Brown Bat, Eptesicus Fuscus. The Chinese Journal of Physiology, 51(1), 13-26. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200802-51-1-13-26-a
Wu, F. J., & Jen, P. H. S. (2009). Involvement of GABA-Mediated Inhibition in Shaping the Frequency Selectivity of Neurons in the Inferior Colliculus of the Big Brown Bat, Eptesicus fuscus. The Chinese Journal of Physiology, 52(1), 38-46. https://doi.org/10.4077/CJP.2009.AMH002
Jen, P. H. S., Wu, M., & Pinheiro, A. D. (1991). Directional Sensitivity of Bat Inferior Collicular Neurons Determined under Normal and Monaurally Plugged Ear Conditions. The Chinese Journal of Physiology, 34(4), 371-386. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199112-34-4-371-386-a
Zhou, X. M., & Jen, P. H. S. (2006). Duration Selectivity of Bat Inferior Collicular Neurons Improves with Increasing Pulse Repetition Rate. The Chinese Journal of Physiology, 49(1), 46-55. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200602-49-1-46-55-a
Fu, Z. Y., Tang, J., Li, Y., Zeng, H., & Chen, Q. C. (2011). Frequency-Modulation Component of the Mimic Echolocation Sound can Increase the Sensitivity of Inferior Collicular Neurons to Sound Amplitude in the Leaf-Nosed Bat, Hipposideros armiger. Zoological Studies, 50(5), 537-545. https://www.airitilibrary.com/Article/Detail?DocID=10215506-201109-201109090015-201109090015-537-545

國際替代計量

GABAergic Inhibition and the Effect of Sound Direction on Rate-Intensity Functions of Inferior Collicular Neurons of the Big Brown Bat, Eptesicus Fuscus

全文下載

主題瀏覽