- 期刊
Environmental Factors Responsible for Variability of Hepatic Vein Flow: A Doppler Assessment in Healthy Twins
並列摘要
Doppler interrogation studies of the liver blood flow indicate altered hepatic vein waveforms in association with impaired hepatocellular function. However, little is known about the mechanisms responsible for variations of these parameters in the absence of disease. We aimed to investigate the contribution of heritable and environmental factors to the physiological variability of hepatic vein flow in a twin cohort. Two hundred twenty-eight healthy adult Hungarian twins (69 monozygotic, 45 same-sex dizygotic pairs) underwent Doppler sonography of the hepatic vein. Age- and sex-adjusted heritability of the highest velocity (amplitude of S wave) of hepatic vein flow was negligible. Shared environment contributed to 33% (95% CI, 16%-51%), and unshared environment was responsible for the largest portion (67%; 95% CI, 49%-84%) of the variance. Duration of sports activities was significantly (P ＜ 0.05) related to the magnitude of hepatic vein flow, while other risk factors and lifestyle characteristics had no significant influence. The data suggest that genetic factors have little impact on the parameters of hepatic venous blood flow. The variability observed in healthy twins by the Doppler interrogation can be explained by the effect of unshared environmental components primarily related to regular physical activity. These findings underscore the importance of unique environments in physiological variations of hepatic venous blood flow.
參考文獻
延伸閱讀
- Pakoz, Z. B., Cekic, C., Arabul, M., Yuksel, E. S., Ipek, S., Vatansever, S., & Unsal, B. (2015). An Evaluation of the Correlation between Hepcidin Serum Levels and Disease Activity in Inflammatory Bowel Disease. Gastroenterology Research and Practice, 2015(), 542-545-176. https://doi.org/10.1155/2015/810942
- Liu, Z., Pan, J., & Zeng, Y. (2021). Information-based Similarity as Novel Heart Rate Variability Indices in Congestive Heart Failure Assessment. International Core Journal of Engineering, 7(9), 349-356. https://doi.org/10.6919/ICJE.202109_7(9).0049
- Moreno, P. M., Expósito, M. R. A., Martínez, A. D. H., Ortega, R. P., Tendero, L. Z., Herrero, J. J. E., & Moreno, M. A. G. (2016). Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism. International Journal of Endocrinology, 2016(), 562-567-062. https://doi.org/10.1155/2016/4581094
- 林文煌（2006）。Preliminary Evaluation of Exercise to Liver Function Variations of Anti-Viral Therapies Received B Hepatitis Patients。福爾摩沙體育學刊，(1)，9-16。https://doi.org/10.29927/JPEF.200612.0002
- JAKAB, F., SUGÁR, I., RÁTH, Z., NÁGY, P., & FALLER, J. (1996). The Relationship between Portal Venous and Hepatic Arterial Blood Flow. I. Experimental Liver Transplantation. HPB Surgery, 1996(), d21-26. https://doi.org/10.1155/1996/90536