Effects of Gamma-Tocopherol Supplementation on Thrombotic Risk Factors

Gamma-生育醇的補充對血栓危險因子的影響

Indu Singh ； Alan H. Turner ； Andrew J. Sinclair ； Duo Li ； John A. Hawley

《Asia Pacific Journal of Clinical Nutrition》 16卷3期 (2007/09) Pp. 422-428

https://doi.org/10.6133/apjcn.2007.16.3.05

摘要

Objective: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (α-T) and gamma-tocopherol (γ-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using α-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d γ-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). Methods and results: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of γ-T and 12 received placebo (soybean capsules with less than 5 mg/d γ-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood γ-T concentrations increased significantly (p＜0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p＜0.05). Subjects consuming 100 mg/d γ-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p＜0.05). Little effect of γ-T was observed on other parameters. Conclusions: These data suggest that γ-T supplementation may have a permissive role in decreasing the risk of thrombotic events by improving lipid profile and reducing platelet activity.

關鍵字

gamma-生育醇 ； 血小板 ； 脂質 ； 血小板危險因子

並列摘要

Objective: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (α-T) and gamma-tocopherol (γ-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using α-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d γ-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). Methods and results: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of γ-T and 12 received placebo (soybean capsules with less than 5 mg/d γ-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood γ-T concentrations increased significantly (p＜0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p＜0.05). Subjects consuming 100 mg/d γ-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p＜0.05). Little effect of γ-T was observed on other parameters. Conclusions: These data suggest that γ-T supplementation may have a permissive role in decreasing the risk of thrombotic events by improving lipid profile and reducing platelet activity.

並列關鍵字

gamma tocopherol ； platelets ； lipids ； CRP ； thrombotic risk factors