Effect of Soy Isoflavone Extract Supplements on Bone Mineral Density in Menopausal Women: Meta-Analysis of Randomized Controlled Trials

大豆異黃酮抽取物的補充劑對停經後婦女骨質密度的效果：隨機對照試驗的後設分析

Kyoko Taku ； Melissa K Melby ； Jun Takebayashi ； Shoichi Mizuno ； Yoshiko Ishimi ； Toyonori Omori ； Shaw Watanabe

《Asia Pacific Journal of Clinical Nutrition》 19卷1期 (2010/03) Pp. 33-42

https://doi.org/10.6133/apjcn.2010.19.1.05

摘要

本研究旨在確認攝取大豆異黃酮抽取物（並非大豆蛋白或含有異黃酮的食品）對停經後婦女骨質密度（BMD）的效果。我們從PubMed，CENTRAL，ICHUSHI，CNKI，Wanfang Data，CQVIP，和NSTL檢索，以英語，日語，或中文發表，並報告大豆異黃酮抽取物對停經後婦女腰椎或髖關節BMD效果的隨機對照試驗論文。依照納入和排除標準，對試驗論文進行鑑別和評閱來判定是否採用。有關研究設計，對象，介入，和結果的數據被抽取出進行分析。最終分別有11、7、5、和5個試驗被採用來評估對腰椎、大腿骨頸部、髖關節全體、和股骨大轉子BMD的效果。包括1240名停經後婦女的後設分析（隨機效果模型）顯示，與對照組相比，每日平均攝取82（47-150）mg的大豆異黃酮（苷元當量）持續6-12個月，顯著地提高腰椎BMD22.25mg/cm^2（95%信賴區間:7.61，32.89；p=0.002），或提高2.38%（95%信賴區間:0.93，3.83；p=0.001）。亞組分析顯示，不同試驗間大豆異黃酮對腰椎BMD的效果各異，可能與介入期間（6或12個月），對象的區域（亞洲或西方），和基礎BMD（正常骨質或骨質減少症或骨質疏鬆症）的研究特徵相關。我們的後設分析沒有發現對大腿骨頸部，髖關節全體，和股骨大轉子BMD的效果。大豆異黃酮抽取物的補充劑提高了停經後婦女的腰椎BMD。需要更深入的研究去闡明影響其對腰椎效果程度的因素，以及驗證其對髖關節的效果。

關鍵字

後設分析 ； 異黃酮 ； 膳食補充劑 ； 停經 ； 骨密度

並列摘要

This study was conducted to clarify the effect of ingesting soy isoflavone extracts (not soy protein or foods containing isoflavones) on bone mineral density (BMD) in menopausal women. PubMed, CENTRAL, ICHUSHI, CNKI, Wanfang Data, CQVIP, and NSTL were searched for randomized controlled trials published in English, Japanese, or Chinese reporting the effects of soy isoflavone extracts on lumbar spine or hip BMD in menopausal women. Trials were identified and reviewed for inclusion and exclusion eligibility. Data on study design, participants, interventions, and outcomes were extracted. Eleven, seven, five, and five trials were finally selected for estimation of the effects on spine, femoral neck, hip total, and trochanter BMD, respectively. Meta-analysis including data from1240 menopausal women revealed that daily ingestion of an average of 82 (47–150) mg soy isoflavones (aglycone equivalent) for 6–12 months significantly increased spine BMD by 22.25 mg/cm2 (95% CI: 7.62, 32.89; p=0.002), or by 2.38% (95% CI: 0.93, 3.83; p=0.001) compared with controls (random-effects model). Subgroup analyses indicated that the varying effects of isoflavones on spine BMD across trials might be associated with study characteristics of intervention duration (6 vs. 12 months), region of participant (Asian vs. Western), and basal BMD (normal bone mass vs. osteopenia or osteoporosis). No significant effects on femoral neck, hip total, and trochanter BMD were found. Soy isoflavone extract supplements increased lumbar spine BMD in menopausal women. Further studies are needed to address factors affecting the magnitudes of effect on spine and to verify the effect on hip.

並列關鍵字

meta-analysis ； isoflavones ； dietary supplements ； menopause ； bone density