Effect of L-arginine on Immune Function: A Meta-Analysis

L-精氨酸通过影响机体免疫应答和炎症反应在免疫调节中发挥重要作用。本meta分析对补充L-精氨酸是否可以改善机体免疫功能的结果进行了评估，同时对补充L-精氨酸的安全性进行了评价。本文检索了四个数据库（PubMed，EMBASE，Web of Science，the Cochrane Library）中自1966至2013年9月发表的有关补充L-精氨酸对免疫功能影响的所有随机对照试验。按照Jadad评分量表对纳入的随机对照研究进行方法学质量评定，并根据异质性检验的结果，选择使用固定或随机效应模型。最终11项试验（包括321名患者）被纳入本次研究。Meta分析结果显示，与对照组相比，L-精氨酸组CD4^+ T细胞的增殖显著增加（MD 5.03；95% CI 1.11，8.95；p＜0.05），且感染并发症的发生率降低（OR 0.40；95%CI 0.17，0.95；p＜0.05）。

關鍵字

L-精氨酸；一氧化氮；免疫；细胞因子； meta分析

並列摘要

L-arginine plays an important role in immune regulation by affecting the immune response and inflammation. This meta-analysis was performed to assess whether L-arginine supplementation could improve the outcomes of immune function, and to evaluate the safety of L-arginine supplementation. Four databases (PubMed, EMBASE, Web of Science, the Cochrane Library) for all randomized controlled trials investigating the effects of supplementation with L-arginine published from 1966 to September 2013 were searched. The quality of controlled trials was assessed with the Jadad method. Meta-analyses were performed with fixed- or random-effects models according to heterogeneity of studies. Data from 11 trials involving 321 patients were enrolled. Meta-analysis showed that the L-arginine supplement group had a significantly greater CD4^+ T-cell proliferation response (MD 5.03; 95% CI 1.11, 8.95; p＜0.05), and that the incidence of infectious complications was lower (OR 0.40; 95% CI 0.17, 0.95; p＜0.05) than control.

並列關鍵字

L-arginine ； nitric oxide ； immune ； cytokines ； meta-analysis

參考文獻

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國際替代計量

Effect of L-arginine on Immune Function: A Meta-Analysis

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