透過您的圖書館登入
IP:18.212.102.174
  • 期刊

Melanocortin-4 receptor rs17782313 polymorphisms are associated with serum triglycerides in older Chinese women

黑色素皮质激素-4受体基因rs17782313多态性与中国老年女性血清甘油三酯的相关性研究

本篇文章尚未正式出版,請點選「加入追蹤」跟進後續出版資訊!

摘要


背景与目的:研究显示高加索人和日本人的黑色素皮质激素-4受体(MC4R)基因多态性与血清甘油三酯(TG)相关,但没有关于中国人的报道。本研究的目的是研究黑色素皮质激素-4受体基因rs17782313多态性是否与中国老年人血清甘油三酯有关。方法与研究设计:本研究采用横断面的研究方法调查了2012位年龄在40岁以上的成年人,测定其体质指数、甘油三酯、高密度脂蛋白胆固醇以及黑色素皮质激素-4受体基因rs17782313多态性等指标。结果:携带T/T基因型的女性血清甘油三酯明显低于携带C/C基因型的女性(p=0.006)。携带C/C基因型的女性的高密度脂蛋白胆固醇则明显低于携带T/T和T/C基因型的女性(p=0.025),但其糖化血红蛋白显著高于携带T/T和T/C基因型的女性(p=0.043),血压无统计学意义。在校正了年龄、吸烟、饮酒、体质指数、腰围和代谢综合征等因素后,多元线性回归分析发现携带C/C基因型的女性有较高的血清甘油三酯(p=0.01)。在女性中,即使校正了年龄、吸烟、饮酒、体质指数和腰围,携带C/C基因型的女性甘油三酯的比值比(OR值)仍然显著高于携带T/C和T/T基因型的女性。结论:中国老年女性的黑色素皮质激素-4受体基因rs17782313的C/C基因型与较高的血清甘油三酯有关。

並列摘要


Background and Objectives: MC4R (melanocortin-4 receptor) gene polymorphisms have been associated with serum triglycerides (TG) in Caucasians and Japanese, but no reports are available Chinese. The purpose of this study was to find whether there was an association of rs17782313 polymorphisms at the MC4R gene with serum TG in elderly Chinese. Methods and Study Design: 2,012 over 40 years participated in a cross-sectional study in which their body mass index (BMI), TG, high density lipoprotein-cholesterol (HDL-C), and MC4R rs17782313 polymorphisms were determined. Results: For women, carriers of the T/T genotype had significantly lower serum TG than those with C/C genotype (p=0.006). Carriers of the C/C genotype of this polymorphisms exhibited significantly lower fasting HDL-C levels compared with T/T and T/C genotypes (p=0.025), and increased glycosylated hemoglobin (HbA1c) (p=0.043), but no change in blood pressure. Higher serum TG in carriers of the C/C genotype of MC4R gene remained stable after adjustment for age, smoking, drinking, BMI, waist circumference (WC) and three or more components of the metabolic syndrome (MS) by multivariable linear regression (p=0.01) in women. The carriers of the C/C genotype of MC4R gene showed significantly greater odds ratio for TG than T/C and T/T genotypes, even when adjusted for age, smoking, drinking, BMI and WC in women. Conclusions: The rs17782313 C/C genotype is associated with higher TG levels in older Chinese women.

延伸閱讀