NF-κB在發炎反應、細胞凋亡與癌症生成過程中的調控

Modulation of Inflammation, Apoptosis, and Oncogenesis by the Nuclear Transcription Factor, NF-κB

鄧富元(Fu-Yuan Teng) ； 龔素芳(Sue-Fang Kung Wu) ； 夏毅然(Yi-Yan Hsia) ； 高文斌(Wen-Bin Kao) ； 謝耀東(Yao-Dung Hsieh)

《中華牙醫學雜誌（中文版）》 25卷1期 (2006/03) Pp. 12-24

https://doi.org/10.7106/CJD.200603.0012

摘要

NF-κB是發炎反應過程中極為重要的分子，當細胞接受到來自細胞外的訊息刺激時，在細胞質中的NF-κB會由原先受IκB抑制的狀態下釋放出，並呈現活化狀態。活化之後的NF-κB進入細胞核中並引發特定基因轉錄及表現，產生後續發炎反應、調控細胞凋亡及進一步導致腫瘤之發生。從發炎反應、細胞凋亡到腫瘤發生的過程中NF-κB一直扮演極重要之角色，因此有必要以文獻回顧方式針對NF-κB在此過程中是扮演何種角色及如何調控發炎反應、細胞凋亡及腫瘤生成做一詳盡之探討。

關鍵字

發炎反應細胞凋亡 ； 腫瘤發生 ； NF-κB

並列摘要

Nuclear transcription factor-κB (NF-κB) is an important factor involved in inflammatory reactions. When a cell receives extracellular stimulation, the NF-κB in the cytoplasm is released and activated from a previously κB-inhibited status. The activated NE-κB then moves into cell nuclei and acts upon promoters of particular genes, resulting in expression of those genes. The expressed genes further lead to an inflammatory reaction, modulation of apoptosis, and initiation of carcinogenesis. It is necessary to elucidate the details of the roles of NF-κB in cell inflammation, apoptosis, and carcinogenesis. This review article discusses the constitution of the NE-κB family, interactions between NE-κB and programmed cell death, the regulating factors and mechanisms involved in activation of NE-κB, the relationship between NE-κB and carcinogenesis, the regulation of NE-κB via tumor-related proteins, and possible tumor treatment through the control of N F-κB.

並列關鍵字

NF-κB ； inflammation ； apoptosis ； tumorigenesis