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Plexiform Neurofibromas with Mast Cell Infiltration of the Gallbladder in a Patient with Cholelithiasis

膽囊結石合併神經纖維瘤及肥胖細胞浸潤:一病例報告及文獻回顧

摘要


膽囊神經纖維瘤為一種少見的良性瘤。本文報告一位八十一歲老先生因膽囊及總膽管結石,施行膽囊切除術。病理鏡檢發現該膽囊除了有結石、慢性發炎外,還可見數個小節結狀的神經纖維瘤位在膽囊壁內。另外,發現許多肥胖細胞(Mast cell)浸潤在神經纖維瘤周圍。鑑於許多文獻已報告神經纖維瘤與肥胖細胞之相關性,我們提出此罕見病例(英文文獻僅見四例),同時討論肥胖細胞與神經纖維瘤之間可能的相關性。

並列摘要


This article describes an unusual case of plexiform neurofibromas incidentally found in the gallbladder resected for cholelithiasis and choledocholithiasis. S-100 protein is detected in the tumor cells. In addition, mast cell infiltration is observed within or/and around the neurofibromas demonstrated by toluidine blue and Giemsa's stains. To our knowledge, mast cell infiltration is found in many reported neurofibromas and has been hypothesized as a possible pathogenesis of these neoplasms. Based on results in this case, we believe that mast cells are also an important associated marker for the plexiform neurofibromas of gallbladder.

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