Psoas abscess is an uncommon disease. It may occur as a primary infection of the psoas space or as a secondary abscess from the direct extension of infection from adjacent organs. Staphylococcus aureus is the primary organism of primary psoas abscesses. Secondary psoas abscess is usually a complication of intestinal diseases, and bacterial culture generally grows mixed enteric organisms. Psoas abscess is often unilateral, and it could rarely presents with bilateral multilobulated abscess. In bilateral cases, it is frequently caused by secondary origin. From Nov. 1998 to Jun. 2000, there were four patients with bilateral pyogenic psoas abscess treated at VGH-Taichung. One case was infected with Fusobacterium varium alone without any definite intestinal disease. After series debridement with appropriate parenteral antibiotics treatment, three patients recovered and one patient expired because severely septic shock. Keeping a high index of clinical suspicion and early diagnosis with computed tomography, the psoas abscess could be managed well with adequate drainage and parenteral antibiotics.