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- OpenAccess
Effect of Surgical Parathyroidectomy on Distress Symptoms and Quality of Life in Patients with End-Stage Renal Disease
並列摘要
BACKGROUND. Advanced secondary hyperparathyroidism is common in dialysis patients. We studied the effect of parathyroidectomy on relieving symptoms of physical distress in patients undergoing dialysis.METHODS. We enrolled 37 dialysis patients who underwent parathyroidectomy at one medical center. Quality of life (QOL) was measured with the Health Survey (SF-36) and distress symptoms were evaluated by the Visual Analogue Scale (VAS).RESULTS. Joint pain, muscle weakness, and itchy skin were the most annoying symptoms. The average serum level of Ca×P was 53.4±14.93 mg^2/dL^2 (38.3±13.9), and the average iPTH level was 2086.3±1452.16 pg/dL (286.6±311.84). Before surgery, the physical component score of the QOL scale was 31.7±13.8 (38.6±13.0, P＜0.001), the mental component score was 37.6±14.4 (40.8±13.1, P＜0.001), and the overall score was 49.1±10.1. Adverse symptoms were reported by 32 (86.5%) patients. Post-surgery, there was a statistically significant reduction in adverse symptoms. There was a positive correlation between the calcium-phosphorus product and skin itching (r=0.363, P=0.027). Before and after surgery, the mean VAS score was 4.31±3.33 (3.0±2.19, P＜0.001) for itching, 4.98±3.37 (2.61±2.19, P＜0.05) for joint pain, and 4.63±2.90 (3.30±2.19) for muscle weakness.CONCLUSION. Parathyroidectomy in dialysis patients with hyperparathyroidism can relieve adverse symptoms and improve their quality of life.
延伸閱讀
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