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The Association of Age, Gender and Metabolic Factors with Gallstone Disease

年齡、性別及代謝因子與膽結石疾病之相關性研究

摘要


研究動機:代謝症候群已被證實為心血管疾病之危險因子。最近研究亦發現代謝症候群與許多消化系統問題顯著相關。本回溯性研究目的在探討代謝因子與膽結石疾病之相關性。病人與方法:我們分析了3990位於本院接受健檢之個案,排除年齡小於20歲(8例)及膽囊息肉症(560例),共3422位納入分析。其中膽結石疾病個案277人為研究組,餘3145人為對照組,納入分析之變項含:年齡、性別、代謝症候群及其各單一代謝因子,希望能找出與膽結石疾病獨立相關之因子。結果:多變項邏輯回歸分析顯示:性別、代謝症候群於兩組間無顯著差異。男、女性分別分析時,男性之膽結石疾病與『年齡≧50歲』(OR:2.47,95% CI:1.71-3.56)及『葡萄糖不耐症』(OR:1.82, 95% CI:1.24-2.67)呈顯著相關;女性之膽結石疾病則與『年齡≧50歲』(OR:2.52, 95% CI:1.64-3.86)及『中央型肥胖症』(OR:1.69,95% CI:1.12-2.53)呈顯著相關。結論:我們的研究顯示膽結石疾病於不同性別有其特殊之代謝表現,應有不同之預防及篩檢策略,以降低其對健康之影響。

並列摘要


Aims: To determine the association of age, gender, metabolic risk factors and gallstone disease in a Taiwanese population.Patients and Methods: We conducted a retrospective case-control study. Between October 2004 and December 2005, 3990 adults who underwent health examinations were enrolled in this study. Subjects with gallstone were diagnosed by ultrasound or by a history of cholecystectomy because of gallstone disease. Gender, age, abdominal girdle, blood pressure, and serum levels of triglyceride, glucose and β-lipoproteins were compared between individuals with and without gallstone disease. We defined metabolic syndrome according to the 2005 International Diabetes Federation criteria, with Asian modification. Multivariate logistic regression analysis was used to identify independent risk factors associated with gallstone disease in males and females.Results: After reviewing the medical records, 277 of 3990 individuals met the criteria of having gallstone disease (males: females = 153/2359 (6.5%): 124/1631 (7.6%)). Participants aged < 20 years (n=8) or with a history of gallbladder polyps (n=560) were excluded, and a total of 3422 individuals were entered into the subsequent analysis. Patients with gallstone disease had significantly increased age, serum fasting glucose level, abdominal girdle and systolic blood pressure as determined by univariate analysis (all p values were < 0.05). The association between metabolic syndrome and gallstone disease was not significant after adjusting for age and gender (OR: 1.23, 95% CI: 0.92-1.65). Multivariate logistic regression analysis revealed that older age (> 50 yr vs. ≤ 50 yr) was significantly associated with gallstone disease in both genders (OR : 2.47, 95% CI : 1.71-3.56 in males; OR : 2.52, 95% CI : 1.64-3.86 in females). Central obesity was significantly associated with gallstone disease in women (OR: 1.69, 95% CI: 1.12-2.53). Glucose intolerance was significantly associated with gallstone disease in men (OR: 1.82, 95% CI: 1.24-2.67).Conclusions: Taiwanese with gallstone disease had specific metabolic profiles. Age was significantly associated with the prevalence of gallstone disease in both genders. Glucose intolerance and central obesity were independent metabolic risk factors for gallstone disease in men and women, respectively. Our results suggest that men and women may need different strategies to reduce the burden of gallstone disease.

被引用紀錄


簡瑋成(2016)。膽結石病患伴隨中風之評估研究〔碩士論文,國立虎尾科技大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0028-2807201615122100

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