- 期刊
Enhanced Expression of C-Ki-Ras Oncogene and High Serum Level of Total Lactic Dehydrogenase in a Papillary Adenocarcinoma of the Ovary
並列摘要
A 57-year old woman was found with a stage III ovarian cancer. Cytoreductive .surgery was done. A preoperative blood sample was obtained for determination of lactic dehydrogenase (LDH). An ovarian tissue specimen was taken for determination of expression of c-Ki-ras oncogene. Serum total LDH level was measured by a blood chemistry automatic analyzer. LDH isozymes activities were determined by electrophretic separation on cellulose acetate membrane. The total LDH level was 2562 IU/ml. The isozymes of LDH-1 to LDH-5 were 21.5%, 35.1%, 20.4%, 9.4% and 13.6, respectively. A 15-fold increase ofc-Ki-ras RNA transcripts was demonstrated. The concomitant elevation of total LDH level and expression of c-Ki-ras may suggest that enhanced expression of ras oncogene results in increased synthesis of p21, which may then transactivate the LDH genes at the transcriptional level.
延伸閱讀
- COLOMBATTI, A., RUSSO, P., CERVI, M., BOGETTO, L., WASSERMANN, B., MAINIERO, F., & SPESSOTTO, P. (2002). Differential expression of IRS-1 and IRS-2 in uterine leiomyosarcomas with distinct oncogenic phenotypes: lack of correlation with downstream signaling events. Sarcoma, 2002(), 89-96. https://doi.org/10.1080/1357714021000065387
- Cheung, M. T. (2011). Expression of met receptor tyrosine kinase in hepatocellularcarcinoma [master's thesis, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200019219
- Lee, C. C., Kuo, W. H., Lin, C. K., Gao, H. W., & Tsai, W. C. (2013). Discrimination of CD44 and Oct3/4 Expression in Pancreatic Adenocarcinoma from Benign Pancreatic Ducts in Small Biopsy Specimens. The Chinese Journal of Physiology, (), 1-8. https://doi.org/10.4077/CJP.2017.BAF446
- Lee, C. C., Kuo, W. H., Lin, C. K., Gao, H. W., & Tsai, W. C. (2017). Discrimination of CD44 and Oct3/4 Expression in Pancreatic Adenocarcinoma from Benign Pancreatic Ducts in Small Biopsy Specimens. The Chinese Journal of Physiology, 60(2), 81-88. https://doi.org/10.4077/CJP.2017.BAF446
- 葛裕民（2007）。Expression of Cyclooxygenase –2, Aromatase, ER and PR and Their Correlation with Clinicopathological Characteristics or Survival in Endometrial Cancer〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2007.00064