Androgen Receptor Gene Polymorphism and Schizophrenia

Hai-Gwo Hwu ； Hey-Chi Hsu ； Chien-Ts Chu ； Chia-Hsiang Chen ； Yi-Ling Lee

《Journal of Genetics and Molecular Biology》 6卷1期 (1995/03) Pp. 1-6

https://doi.org/10.30047/JGMB.199503.0001

並列摘要

To clucidate the role of schizophrenia candidate genes on the X-chromosome, we conducted an association study of 69 (male 41, female 28) schizophrenia patients, 64 (male 36, female 28) normal first degree relative (FDR) and 47 (male 33, female 14) normal control subjects, using polymorphism of (CAG)n repeats of exon 1 of the androgen receptor gene (Xq11.2-q12) as a marker. Polymerase chain reaction (PCR) products longer that 434 bp were defined as allele group 1, while those shorter than or equal to 434 bp were allele group II.
The frequency of allele group I in the schizophrenic patients, normal FDRs and normal controls was 56.7%, 63.0% and 68.9% respectively. Allele group II in the schizophrenic patients, normal FDRs and normal controls were 43.3%, 37.0% and 31.1% respectively. There was a tendency of increased frequency of allele group II in schizophrenic patients, but it was not statistically significant. Those subjects with allele group II were 36 (52.2%), 29 (45.3%), and 17 (36.2%) in the schizophrenic, normal FDR and normal control subjects respectively. On the other hand, those cases without allele group II were 33 (47.8%), 35 (54.7%), 30 (63.8%) in the schizophrenic, normal FDR and normal control subjects respectively. There was a higher frequency (x2=2.89, df=1, p＜0.01) of allele group II in the schizophrenic cases.

並列關鍵字

androgen receptor gene ； polymorphism ； schizophrenia