The most important characteristic of animal distinguishing from plant and fungus is sensation, although prokaryote has primitive sensory ability. The principal sensory components include vision, olfaction and hearing. This paper reviews the molecular bases for these sensations and proposes some insights in order to further promote the study. Then, it points out the evolutionary implication for these sensory molecules, in which the rhodopsins are likely more clear, the olfactory receptors are limited in a few of species, the prestins or the members of transient receptor potential responsible for hearing are still unclear. I expect the progress of comparative genomics and then proteomics will provide more and more evidence, and the advances in bioinformatics will help data analyses for sensory molecules.
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