From the root of Mimosa pudica L. (Fabaceae), two new diterpenoids, named 19-O-transferuloyl-labd-8(17)-en-15,19-diol (1) and 19-O-[(E)-3',4'-dimethoxy cinnamoyl]-labd-8(17)-en-15,19-diol (2) had been isolated. Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. Compounds 1-2 showed antimicrobial activity against two yeast and two bacteria tested. The strongest activity was observed against Malassezia pachydermatis, followed by Candida albicans and Staphylococcus aureus in the range of 12-16 mm.