鱗狀上皮細胞癌抗原在口腔鱗狀上皮細胞癌患者遠端轉移之分析

背景：血液中的鱗狀上皮細胞癌抗原濃度，已經被廣泛應用在許多部位的鱗狀上皮細胞癌上，而且被證實為一有用的腫瘤標誌。先前的文獻已經探討它與口腔鱗狀上皮細胞癌患者臨床病理因子間的關係，然而鱗狀上皮細胞癌抗原對於患者預後及預測遠端轉移的價值仍有待進一步探討。方法：我們以回溯性研究方式追蹤自2008至2011年，共110名口腔鱗狀上皮細胞癌患者（不含口咽　癌與下咽癌的患者），紀錄和進一步分析這些患者的臨床病理因子、手術前和治療後的鱗狀上皮細胞癌抗原濃度。結果：鱗狀上皮細胞癌抗原濃度陽性（≥ 2.0 ng/ml）和腫瘤大小（p ＜ 0.001）、腫瘤病理分期（p = 0.001）、病理淋巴結轉移（p = 0.030）、淋巴結莢膜外侵犯（p = 0.030），無病存活率（p = 0.007）和全存活率（p = 0.016）之間有顯著的相關；且鱗狀上皮細胞癌抗原陽性（≥ 2.0 ng/ml）患者的遠端轉移比率比陰性（＜ 2.0 ng/ml）患者高（p = 0.019）。結論：此研究顯示，口腔鱗狀上皮細胞癌患者術前血液中的鱗狀上皮細胞癌抗原濃度，可以做為預測病患治療後遠端轉移風險的腫瘤標誌。

關鍵字

鱗狀上皮細胞癌抗原；口腔鱗狀上皮細胞癌；預後；遠端轉移

並列摘要

Background: Squamous cell carcinoma antigen (SCC-Ag) level was widely used as tumor marker in various human squamous cell carcinomas. It was found to be related to the clinicopathological factors in oral cavity squamous cell carcinoma (OSCC) patients. However, the prognostic value of SCC-Ag and its association with distant metastasis is still uncertain. Methods: We retrospectively analyzed one hundred and ten OSCC patients between 2008 and 2011. The clinicopathologic factors and preoperative and post-treatment serum SCC-Ag levels were recorded. Results: The SCC-Ag level greater than 2.0 ng/ml was significantly associated with the clincopathologic factors including larger tumor size (p ＜ 0.001), advanced pathological stage (p = 0.001), positive pathologic nodes (p = 0.030), extracapsular spreading of the lymph nodes (p = 0.030), shorter disease-free survival (p = 0.007) and overall survival (p = 0.016). The distant metastatic rate is higher in SCC-Ag-positive (≥ 2.0 ng/ml) patients compared to SCC-Ag negative(＜ 2.0 ng/ml) patients (p = 0.019). Conclusions: The study revealed that preoperative SCC-Ag is a useful marker to identify OSCC patients with risk of distant metastasis.

並列關鍵字

squamous cell carcinoma antigen ； oral squamous cell carcinoma ； prognosis ； distant metastasis

國際替代計量

鱗狀上皮細胞癌抗原在口腔鱗狀上皮細胞癌患者遠端轉移之分析

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