Quantitative Measurement of Macaque Lateral Geniculate Nucleus after Experimental Glaucoma

獼猴外側滕狀體經實驗性青光眼後之定量分析

周秉義(Ping-I Chou) ； 李驊(Hwa Lee) ； Alfredo A. Sadun

《中華民國眼科醫學會雜誌》 34卷1期 (1995/03) Pp. 1-7

https://doi.org/10.30048/ACTASOS.199503.0001

摘要

This study describes the quantitative transsynaptic atrophic effect on the neurons of the lateral geniculate nucleus(LGN) after experimental glaucoma. All 6 layers of bilateral LGN were measured in one macaque monkey with unilateral experimental glaucoma. Using a semi-automated image analysis system, we measured and counted every neuron in a cross section that traversed all layers of the LGN. We analyzed the cell soma area, equivalent diameter and cell density for each layer. The average cell area and equivalent diameter were significantly decreased in all layers receiving input from the glaucomatous eye (P＜0.05). The magnocellular layer had a greater percent reduction in both average cell area and equivalent diameter than that observed in the parvocellular layer, suggesting that these layers are more susceptible to glaucomatous damage. The mean magnocellular and parvocellular cell density that receiving glaucornatous input was significantly reduced (P＜0.05). This may reflects a differential effect of disease on the two nerve fiber types or alternatively there may be an intrinsic magnocellular vs parvocellular difference in the resiliency of LGN neurons.

並列摘要

This study describes the quantitative transsynaptic atrophic effect on the neurons of the lateral geniculate nucleus(LGN) after experimental glaucoma. All 6 layers of bilateral LGN were measured in one macaque monkey with unilateral experimental glaucoma. Using a semi-automated image analysis system, we measured and counted every neuron in a cross section that traversed all layers of the LGN. We analyzed the cell soma area, equivalent diameter and cell density for each layer. The average cell area and equivalent diameter were significantly decreased in all layers receiving input from the glaucomatous eye (P＜0.05). The magnocellular layer had a greater percent reduction in both average cell area and equivalent diameter than that observed in the parvocellular layer, suggesting that these layers are more susceptible to glaucomatous damage. The mean magnocellular and parvocellular cell density that receiving glaucornatous input was significantly reduced (P＜0.05). This may reflects a differential effect of disease on the two nerve fiber types or alternatively there may be an intrinsic magnocellular vs parvocellular difference in the resiliency of LGN neurons.

並列關鍵字

Lateral geniculate nucleus LGN ； transsynaptic atrophy ； magnocellular ； parvocellular