Clinical Characteristics of Corneal Ulcer in Hsin Chu General Hospital

目的：分析新竹醫院連續八年角膜潰瘍的臨床表徵。方法；這是一篇回溯性的研究，分析從2002年一月至2009十二月，在新竹醫院臨床珍斷為角膜潰瘍病患的危險因子、微生物研究、治療和結果。結果：診斷角膜潰瘍的150例，90例為男性、60例為女性。平均年齡為45.2±21.5歲，最常見的危險因子為外傷（n=55，46.2％），其次為隱形眼鏡（n=37，31.1％），慢性疾病相關（n=21，17.6％），和手術相關（n=6，5.0％）。大部份的外傷相關的角膜潰瘍，患者為男性（78％）。隱形眼鏡相關的年齡較低（22.2±6.0歲）。最常見的茵株是Pseudomonas species（42.5％）、其次依序是Staphylococcus species（12.3％）、Propiobacterium acnes（8.2％）、和Fungi（7.9％）。大多數的患者經由藥物可以治療控制（90.7％）。結論；外傷在新竹地區的角膜潰瘍是最常見的危險因子，但是隱形眼鏡在研究的後期有增多的趨勢。Pseudomonas species是八年研究中最常見的菌株。這篇研究提供了區域性的角膜潰瘍的相關資料並且輔助日後治療的方向。

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並列摘要

Purpose: To analyze the clinical characteristics of corneal ulcer at Hsinchu General Hospital in the preceding 8 years. Methods: This is a retrospective cross-sectional study. Medical records were reviewed for patients with clinically diagnosed corneal ulcer at Hsinchu General Hospital from January 2002 to December 2009. The predisposing factors, microbial isolation, and treatments were reviewed. Results: Corneal ulcer was diagnosed in 150 eyes of 147 patients. There were 90 males and 60 females. The mean age was 45.2 ± 21 .5 years. The most common predisposing factor was trauma (n=55, 46.2%), followed by contact-lens wear (n=37, 31.1 %), chronic ocular and systemic disorder (n=21, 17.6%) and recent ocular surgery(n=6, 5.0%). Seventy-eight percent of patients with the predisposing factor of trauma were male. The mean age of patients with contact-lens wear was young (mean age 22.2 6.0). The most common pathogen was Pseudomonas species (42.5%), followed by Staphylococcus species (12.3%), Propiobacterium acnes (8.2%), and Fungi (7.9%). Medical success was achieved in 90.7% of eyes, while 14 eyes (9.3%) required further surgical intervention. Conclusions: Trauma-related corneal ulcer was the most common form of keratitis in our patient population, but contact lens use became the chief predisposing factors in the second half of the study period. The Pseudomonas species was the most commonly found isolate over the 8-year study period. These findings will provide background information and facilitate successful treatment in the Hsinchu area.

並列關鍵字

Corneal Ulcer ； Microbial Keratitis ； Eye Infection

國際替代計量

Clinical Characteristics of Corneal Ulcer in Hsin Chu General Hospital

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