The Role Of 99mtc-Ecd Brain Spect in Patients with Persistent Complaints and Normal Computed Tomography after Mild or Moderate Traumatic Brain Injury: A Preliminary Report

利用鎝-99m-ECD腦部單光子射出斷層掃描來評估電腦斷層檢查為正常的輕度或中度腦部外傷病患之局部腦血流的改變：先期研究

李文源(Wen-Yuan Lee) ； 孫盛生(Shung-Shung Sun) ； 蔡世傳(Shih-Chuan Tsai) ； 鄧山階(Shan-Chieh Teng) ； 賴雅慧(Ya-Hei Lai) ； 高嘉鴻(Chia-Hung Kao)

《核子醫學雜誌》 13卷4期 (2000/12) Pp. 203-207

摘要

背景：本先期研究的目的在於評估鎝-99m-ECD腦部單光子射出斷層掃描的臨床角色用於評估電腦斷層掃描為正常的輕度或中度腦部外傷而持續有神經學方面症狀抱怨的病患。方法：本研究收集了18名輕度或中度腦部外的患者，所有病人全部接受過電腦斷層之檢查，其結果皆為正常。之後安排所有病患接受鎝-99m-ECD腦部單光子射出斷層掃描之核醫檢查。結果：核醫之鎝-99m-ECD腦部單光子射出斷層掃描檢查顯示在18名病患中，有11位發現不正常的腦血流減少現象。結論：本研究結果顯示核醫之鉻-99m-ECD腦部單光子射出斷層掃描為一種高靈敏度的檢查，可以提供一個客觀的證據來解釋這些輕度或中度腦部外傷且電腦斷層正常的患者之臨床症狀。

關鍵字

鎝-99m-ECD腦部單光子射出段層掃描 ； 腦部外傷

並列摘要

Background: Head trauma is a cause of significant morbidity and mortality in all societies. The purpose of this preliminary study was to evaluate the potential usefulness of(superscript 99m)Tc-ethyl cysteinate dimer(ECD)single photon emission computed tomography(SPECT)inpatients with persistent clinical symptoms and absence of morphological abnormalities using computed tomography(CT)after mild or moderate closed head injury. Methods: Our study included 18 patients who suffered from persistent clinical complaints after mild or moderate closed head trauma. The most common complaints were headache, poor memory and dizziness. However, the results of brain CT scan revealed negative findings in all patients. All patients received the(superscript 99m)Tc-ECDSPECT brain imaging(9 studies performed within 6months of the date of injury and 9 studies performed more than 6 months post-injury).None of these patients had previous traumatic brain injury, CVA, psychiatric disorders or history of drug or alcohol abuse. Results: The results of(superscript 99m)Tc-ECD SPECT brain imaging showed that 7 patients had normal study and 11patients were abnormal(one in the frontal lobe, nine in the temporal lobe and one in the frontal and temporal lobes).Conclusion: Through our study, we conclude that(superscript 99m)Tc-ECD SPECT brain imaging is a useful imaging method, as a complement to CT, for evaluation of cerebral perfusion changes following mild or moderate traumatic brain injury in morphologically intact brain regions and providing objective evidence for persistent clinical symptoms.

並列關鍵字

99mTc-ECD brain SPECT ； traumatic brain injury