A 66-year-old woman complained right epigastric pain off and on for 2 years. She was referred to our hospital because sonography showed a hyperechoic nodule in the lower portion of her right hepatic lobe(segmental6).The computerized tomography showed a feature of focal nodular hyperplasia(FNH).The magnetic resonance image was non-diagnostic between hepatocellular carcinoma(HCC)and FNH. Both serum alpha fetoprotein and carcinoma embryonic antigens are in normai ranges. Radionuclide colloid liver scintigraphy showed a photopenic area in the corresponding site seen on the radiological examinations. Histologic analysis indicated a picture of HCC with cirrhosis. FNH is a benign liver abnormality. No therapy is recommended unless complications occur. HCC, on the other hand, is fatal malignancy. Cirrhosis and HCC have become common causes of people death in Taiwan. Differential diagnosis between FNH and HCC is thus clinically important.