Pain is one the most common reasons why patients seek emergency care. Pain is not only an inherently unhealthy condition, but it also has multiple deleterious effects on cardiovascular, respiratory, renal, hemostatic, metabolic, and immune founctions. This paper describes the challenges of pain management in the emergency department (ED), including the widespread problem of oligoanalgesia, various techniques of pain measurement, and the competing priorities of pain management. A number of common therapeutic pitfalls await emergency care doctors who manage acute pain, including poor analgesic selection, opio;hobia, analgesic underdosing, improper frequency, and the use of unnecessary opioid adjuncts. Recommenda-tions are made for managing the pain associated with several common clinical problems seen in EDs, including acute abdominal pain, renal colic, migraine headache, and so-called drug-seeking behavior.