Structural change has been quite an important issue in the field of International Political Economy (IPE). Given that the British school of IPE burdens itself with promoting structural change, this paper introduces works of two emblematic figures in British IPE and their theorization of structure and power. It illustrates the contribution and limitation of S. Strange and R. Cox by re-interpreting American hegemony on Internet Governance through the lens of their works. By doing so, this paper discovers that, when the Internet was set out, the American hegemony in Internet establishes itself on a market-led rulemaking model as prescribed by the configuration of basic structures. Over the course when basic structures turn to favor state-led model, the American hegemony can only relies on advantages bestowed by knowledge structure. Nevertheless, to become a theoretical building that accommodates structural change, British IPE still needs to overcome its lack of elaboration on rules for inter-structure competition in determining the decisive structure change.