Clinical Manifestations of Pulmonary Disease Due to Mycobacterium gordonae: A Case Series from a University Hospital in Taiwan

肺部Mycobacterium gordonae感染之臨床表現：自1998至2001在一臺灣大學醫院之病例系列報告

賴志政(Chih-Cheng Lai) ； 李麗娜(Li-Na Lee) ； 薛博仁(Po-Ren Hsueh) ； 丁良文(Liang-Wen Ding) ； 楊泮池(Pan-Chyr Yang)

《胸腔醫學》 20卷5期 (2005/10) Pp. 403-410

https://doi.org/10.29806/TM.200510.0007

摘要

前言：雖然Mycobacterium gordonae在人類常被視為非病源菌，但仍有少數零星病例報告。本研究的目的在於探討其在肺部感染之臨床表現。
研究方法：我們收集四年內在本院所有培養出分支桿菌的呼吸道相關之檢體並回顧這些患者的病歷及臨床資料，從中找出M. gordonae肺部感染的病人加以分析。
結果：總計有88株M. gordonae自71位患者的呼吸道檢體培養出，其中有8位患者被認定為有M. gordonae的肺部感染。男女的比例為5:3，其中4位患者有糖尿病3位患者有癌症。多數患者(87.5%)的白蛋白是偏低的。這些患者的胸部X光並無特異性。大部分的患者對治療的反應皆不錯。
結論：儘管M. gordonae肺部感染相當罕見，但其一旦反覆自痰液被培養出且合併不明原因的肺部發炎仍需考慮把M. gordonae當病原菌看待。

關鍵字

Mycobacterium gordonae ； 非分支結核桿菌 ； 肺部感染

並列摘要

Background: Mycobacterium gordonae is typically regarded as a colonizing organism that rarely causes pulmonary disease in humans. The aim of this study was to analyze the clinical features of pulmonary M. gordonae disease.
Patients and methods: We retrospectively analyzed all mycobacterial cultures of respiratory specimens at our institution over a 4-year period. The medical and chest radiography records of these patients were reviewed to identify patients who met the American Thoracic Society diagnostic criteria for nontuberculous mycobacterial pulmonary infection.
Results: A total of 88 isolates of M. gordonae were recovered from the respiratory specimens of 71 patients. Eight patients were identified with M. gordonae pulmonary disease. Five of these patients were female, 4 had diabetes mellitus, and 3 had malignancy. Hypoalbuminemia was noted in 7 (87.5%) patients. No specific chest radiographic patterns were found. Four patients who received antimycobacterial therapy for more than 6 months had clinical, microbiological and radiographic improvement. Three patients died within 1 month after the start of antimycobacterial therapy. One patient received treatment for 1 month, and then was lost to follow-up. The overall survival rate of the 7 patients who could be followed up in our study was 57%.
Conclusion: Although M. gordonae is a rare cause of pulmonary disease, its recovery from sputum specimens in patients with unexplained pulmonary infection should be considered as the sign of a potential respiratory tract pathogen.

並列關鍵字

Mycobacterium gordonae ； nontuberculous mycobacteria ； pulmonary infection