Lung Adenocarcinoma with Penile Metastasis-A Case Report

陰莖轉移是肺癌中少見的轉移，這類轉移多在肺癌晚期才會出現，因此病人大多預後不佳，過去關於這類病例報告並不多，其中多數為鱗狀上皮細胞癌出現的轉移，我們描述一個六十六歲肺腺癌的患者，初期診斷為第四期併肝臟轉移(T2N3M1)，在經過四個療程第一線化學治療（gemcitabine跟cisplatin）後，病人因嚴重的噁心嘔吐而暫停治療，之後病人因食慾不佳而入院，住院期間發現病人出現包皮與陰囊腫脹，經檢查發現有陰莖硬塊，切片與免疫螢光染色後發現CK與TTF-1呈現陽性反應，確定為肺腺癌轉移，病人之後因狀況不佳未接受進一步治療並於兩個星期後死亡。

關鍵字

肺癌；腺癌；陰莖轉移

並列摘要

Metastasis to the penis is very rare in lung cancer, especially adenocarcinoma. We describe a patient with adenocarcinoma of the lung who developed a metastatic lesion in the penis. A 66-year-old Taiwanese male was diagnosed with adenocarcinoma of the lung at stage IV (T2N3M1, liver metastasis), and was treated with chemotherapy consisting of gemcitabine, cisplatin and bevacizumab, beginning on 21 September 2005. Three months later, hardness of the penile shaft was noted. A biopsy of the penis was performed, which provided a histological diagnosis of adenocarcinoma. The histology of the specimen was consistent with that of the previous lung cancer, so he was considered to have penile metastasis from adenocarcinoma of the lung. However, a poor performance status was noted, and the patient could not tolerate the chemotherapy. The patient expired 2 weeks later due to cancer progression. We review the reported cases to investigate the clinical characteristics of this rare involvement.

並列關鍵字

lung cancer ； adenocarcinoma ； penile metastasis

國際替代計量

Lung Adenocarcinoma with Penile Metastasis-A Case Report

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