Interferon-alpha Therapy plus Ribavirin Successfully Treat Acute Flare-up of Hepatitis C during Anti-Tuberculous Treatment

成功以干擾素合併Ribavirin治療在一合併肺結核及C型肝炎患者接受抗結核藥物過程中產生之急性肝炎─一病例報告及文獻回顧

李孟叡(Meng-Rui Lee) ； 王振源(Jann-Yuan Wang) ； 李麗娜(Li-Na Lee)

《胸腔醫學》 26卷6期 (2011/12) Pp. 352-356

https://doi.org/10.29806/TM.201112.0007

摘要

對合併有慢性C型肝炎的肺結核病人，處理抗結核藥物治療過程中產生的急性肝炎是個複雜的議題。我們報告一位合併慢性C型肝炎和肺結核的病人在使用抗結核藥物後產生急性肝炎，我們在嘗試逐一重新加入抗結核藥物卻失敗之後，成功地以干擾素合併ribavirin治療C型肝炎，使肝指數降低，進而完成整個抗結核藥物治療過程。（胸腔醫學2011；26：352－356）

關鍵字

C型肝炎 ； 肺結核 ； 干擾素

並列摘要

Hepatitis during anti-tuberculous treatment (HATT) is a complex issue for patients with chronic viral hepatitis C, especially when it recurs after re-challenging the anti-tuberculous drugs. Concerns exist about the safety profile and efficacy of interferon-alpha therapy for active hepatitis C in patients with pulmonary tuberculosis. Herein, we report a 43-year-old man who developed an acute flare-up of hepatitis C during anti-tuberculous treatment and was successfully treated with interferon-alpha and ribavirin. The reduction of liver enzymes correlated well with the hepatitis C viral load, thus enabling the re-challenge with isoniazid and rifampin. This case demonstrates the benefit of interferon-alpha therapy in managing an acute flare-up of hepatitis C during anti-tuberculous treatment. (Thorac Med 2011; 26: 352-356)

並列關鍵字

hepatitis C ； tuberculosis ； interferon