Menstrual abnormalities may occur in women with pulmonary tuberculosis (TB). The association between non-genital TB and amenorrhea is not well understood. We present the case of a 22-year-old unmarried woman who suffered from secondary amenorrhea before and during anti-TB treatment, and who recovered spontaneously thereafter. This case demonstrates that gynecologists should always consider pulmonary TB as a possibility in women presenting with menstruation abnormality in a TB endemic area, and physicians should pay attention to menstruation issues when treating women with TB who are of reproductive age. Gynecologist consultation may be necessary in order to prevent permanent infertility.