鼻咽癌與治療前EB病毒VCA抗體指數的關係

目的：探討放射線治療前EB病毒VCA抗體指數和鼻咽癌患者臨床表徵的關係，並分析抗體指數高低與預後的關係。材料及方法：自1991年4月至1995年9月，有101位患者於治療前一個月內曾接受EB病毒VCA抗體的測試。我們作抗體幾何平均指數及血清陽性率對性別、年齡、WHO組織學形態和臨床分期等臨床因素關係的分析，並分析鼻咽癌之預後因子及EB病毒VCA抗體值與預後的關係。結果：101位患者VCA-IgA及IgG抗體的幾何平均指數分別為102及1316 ，而血清陽性率分別為87.00％及91.70%。 VCA-lgA幾何平均指數在女性明顯較高(p=0.040), IgA血清陽性率則於年長及疾病期別高的患者有明顯偏高(p=0.047及0.015)。而VCA-IgG抗體和這些臨床表徵並無密切關係。鼻咽癌預後和性別及疾病期別有關。而VCA抗體陽性與否和抗體高低皆與預後無關。結論：雖然治療前的VCA抗體幾何平均指數有隨期別增加而增加的趨勢，但無明顯差異。而VCA-IgA血清陽性率和年齡、下期別及AJCC分期有相陽性，此外，VCA抗體值並不可作為推測預後的因素。

關鍵字

鼻咽癌； EB病毒； VCA抗體；預後

並列摘要

-Purpose: To assess the relationship between the pre-RJT EBV VCA titers and the characteristics of the patients with NPC and to analyze the prognostic value of the titers Materials and Methods: From April 1991 to September 1995, 101 patients with nasopharyngeal carcinoma who received the examination of EBV VGA titers before radiotherapy were reviewed. We analyzed the correlation between titers and clinical characteristics, including genders, age, WHO histologic types and stages. We also tried to find the role of these titers in predicting prognosis. Results: We found that the geometric mean titers of EBV VCA-IgA and IgG of these 101 patients were 102 and 1136 and the seropositive rates were 87% and 91.7%, respectively. The GMTs of IgA and IgG trended to be increased in advanced stages, but no significant difference in statistics. There is no significant difference of GMT5 in other clinical features, except IgA titer in sex. The seropositive rates were higher in elders, higher T stage and advanced stage. The role in predicting prognosis was not found. Conclusions: The pre-treatment EBV VGA GMTs increased in advanced stages, but the difference was not significant and they were not proper factors in predicting prognosis.

並列關鍵字

Nasopharyngeal carcinoma ； Eli virus ； Viral capsid antigen ； Prognosis

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鼻咽癌與治療前EB病毒VCA抗體指數的關係

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