The study described the nursing experience of caring for a patient with spinal cord injury and the subsequent hopelessness after car accident. The study employed field research method by means of observation, interview, and listening techniques to collect data. After that, fifteen processing records were completed and analyzed. In this study, Herth Hope Index (Cognitive-temporal dimension, Affective-behavioral dimension, Affiliate-contextual dimension) was adopted to identify that the patient’s major nursing problems included anxiety and hopelessness. According to human caring, the trust relationship between the patient mid the nursing staff was hence created. Moreover, the patient's worries and fears were gradually revealed by in-depth and frequent interactions. Secondly, for the purposes of maintaining value-belief and hope, the patient was successfully encouraged by introducing sonic social resources and inspirational cases. Consequently, the patient has been progressively encouraged to recover her self-confidence and consider the deeper meaning of life. Accordingly, the patient conquered the hopelessness.