Blastic NK-Cell Leukemia / Lymphoma:A Case Report

胚母自然殺手細胞淋巴瘤：病例報告

林俊銘(Chun-Ming Lin) ； 王淑惠(Shu-Hui Wang) ； 郭承統(Tseng-Tong Kuo) ； 紀景琪(Ching-Chi Chi) ； 何信君(Hsin-Chun Ho) ； 洪宏翔(Hong-Shang Hong)

《中華皮膚科醫學雜誌》 21卷4期 (2003/12) Pp. 408-412

https://doi.org/10.29784/DS.200312.0014

摘要

胚母自然殺手細胞淋巴瘤是一種非常罕見且原因不明的惡性淋巴瘤，它是多發性的，但以皮膚最常見。我們報告一位35歲男性病例自六個月前開始在臉部和軀幹出現一些紫紅色斑塊，經皮膚切片檢查發現在真皮及皮下組織有很多類似胚母細胞樣的淋巴細胞，而免疫組織染色可發現這些細胞都呈現CD56、CD45陽性，不過其他T細胞抗原，B細胞抗原和骨髓系標誌的染色則都是陰性。T細胞接受器沒有基因重組現象，EBV核糖核酸的檢查也是陰性；另在其骨髓檢查亦可發現很多與皮膚一樣的CD56陽性淋巴細胞，所以這是一例典型胚母自然殺手細胞淋巴瘤的病例。因為它非常罕見，所以我們報告這個病例。

並列摘要

Blastic natural killer(NK) cell lymphoma/leukemia is a rare NK cell malignancy of unknown etiology. It occurs in multiple sites and with a propensity for skin involvement. We report such a case in a 35-year-old male suffering from erythematous and purpuric papules and plaques on his face and trunk for 6 months. A biopsy specimen of the skin showed diffuse infiltration of blast-like lymphoid cells in the dermis and subcutis. Immunohistochemical study showed the tumor cells were only positive for CD56 and CD45 and negative for other T-cell, B-cell, and myeloid cell markers. T-cell receptor (TCR) gene rearrangement was germline. In situ hybridization for Epstein-Barr virus (EBV) encoded small ribonucleic acid was negative. Aspiration specimen of the bone marrow revealed diffuse infiltration ofCD56+ lymphoid cells in interstitial spaces. The diagnosis of a blastic NK-cell lymphoma/leukemia was made. Because of its rarity, the case is reported.

並列關鍵字

Blastic NK-cell lymphoma ； CD56 ； EBV