- 期刊
溫熱式腹內化學治療和細胞減積手術在大腸直腸癌合併腹膜轉移病人之照護
Care of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Cytoreductive Surgery in Colorectal Cancer with Peritoneal Metastases
摘要
大腸直腸癌高居國人癌症死因的第三名，且根據腫瘤發展的病理路徑，大腸直腸癌常合併腹膜腫瘤轉移發生，當疾病復發及轉移後，病人平均存活期約只有6－8個月，常被視為是不可治癒且預後不佳的疾病，多數病人多採取姑息性治療為主，但近年來將腹膜轉移視為是局部－區域性的擴散過程，發展出溫熱式腹內化學治療合併細胞減積手術，術後的五年存活率已大幅改善。本文整理近期大腸直腸癌合併腹膜轉移之病理機轉、溫熱式腹內化學治療及細胞減積手術概念、手術治療過程、術後相關合併症及照護文獻，提升臨床醫護人員對於手術方式及術後照護進一步的認識，提供病人更優質的健康照護。
並列摘要
Colorectal cancer (CRC) is the third leading cause of cancer-related death in Taiwan. According to the pathological pathway of tumors, peritoneum is a frequent site for metastases in colorectal cancer. Once a patient has developed colorectal cancer with peritoneal metastases, survival duration is only approximately 6-8 months. Such disease with poor prognosis is considered incurable; thus, most patients choose palliative therapy for treatment. However, studies in recent years have regarded peritoneal metastases as having local-regional dissemination. Hence, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy has been developed; the 5-year survival rate of this treatment constitutes a considerable improvement. This article summarized the pathogenesis of colorectal cancer with peritoneal metastases, as well as the concept, process, postoperative complications, and patient care of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. This article provided among professionals with further insight regarding the aforementioned surgery and postoperative care, thereby enabling patients to receive more effective health care.
被引用紀錄
延伸閱讀
- Ling, M. S., Liang, J. T., Huang, J., & Lin, B. R. (2017). 大腸直腸癌合併腹膜內轉移之病人接受腹腔內高溫化學治療的可行性與短期預後. 中華民國大腸直腸外科醫學會雜誌, 28(1), 27-33. https://doi.org/10.6312/SCRSTW.2017.28(1).10525
- Liu, H. W., Lee, H. H. C., & Sung, Y. C. (2015). 第二期大腸癌病人開刀後存活分析：著眼於化學治療－單一醫學中心的經驗. 台灣癌症醫學雜誌, 2(4), 293-300. https://doi.org/10.6323/JCRP.2015.2.4.3
- 趙頌慈、黃文聰、曹朝榮（2018）。淺談腫瘤減積手術及腹腔溫熱化學治療。奇美醫訊，(123)，31-33。https://www.airitilibrary.com/Article/Detail?DocID=P20180523001-201812-201811230007-201811230007-31-33
- Wang, C. C., Tsai, C. L., Chen, Y. H., Liang, J. T., Shieh, M. J., Lin, B. R., Lin, Y. L., & Cheng, J. C. H. (2013). 術前俯臥弧形調控放射治療合併化學治療於局部嚴重性直腸癌之可行性研究. 放射治療與腫瘤學, 20(1), 13-22. https://doi.org/10.6316/TRO/201320(1)13
- Tentes, A. A. K., Kyziridis, D., Kakolyris, S., Pallas, N., Zorbas, G., Korakianitis, O., Mavroudis, C., Courcoutsakis, N., & Prasopoulos, P. (2012). Preliminary Results of Hyperthermic Intraperitoneal Intraoperative Chemotherapy as an Adjuvant in Resectable Pancreatic Cancer. Gastroenterology Research and Practice, 2012(), 519-523-078. https://doi.org/10.1155/2012/506571