Background: Tuberous sclerosis complex is a genetic disorder affecting multiple organs including the heart, lungs, brain, skin, and kidneys. But manic features are seldom documented in a previous literature review. Case Report: The female adolescent patient had tuberous sclerosis complex manifesting with manic symptoms. Her initial presentation included akathisia, poor concentration and queer behavior such as spinning around during her preschool years. She did not get a satisfactory treatment effect with medication under an original suspicion of absence seizure. Based on cutaneous findings such as hypomelanotic macules, a shagreen patch and facial angiofibromas, the diagnosis of tuberous sclerosis complex was confirmed at age 10 years. Her first manic episode appeared when she was 18 years old. Conclusion: Clinicians should be alert to have the possibility of tuberous sclerosis complex with the presentation of any specific cutaneous findings along with seizure attacks. Secondary mania may be associated with tuberous sclerosis complex although further genetic research are needed to clarify the etiological relationship.