Background: Post-stroke mania has rarely been reported, and the lesions of most reported cases have been involved in the non-dominant hemisphere of the brain. We reported a case of mania probably secondary to stroke with a lesion in the dominant hemisphere. Case Report: A 22-year-old, right-handed male patient had a history of pediatric stroke involved in the left middle cerebral artery territory of the brain. He became depressed right after the stroke, and five years later he developed a manic episode. He received lithium and risperidone with satisfactory response. Conclusion: The brain lesion other than laterality may play an important role on the etiology of mania. The research on secondary mania after the stroke is needed to explore the relationship between mood and brain functional region.
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