Current wind-resistant design of wind-sensitive structures including large-scale cooling towers is generally carried out with respect to synoptic boundary-layer-type strong winds. Aswirling tornado can produce significantly different wind pressures than conventional boundary-layer wind. This paper presents both stationary and translating tornado effects on a cooling tower in a tornado vortex simulator developed at Tongji University, China. Wind pressures acting on the external surface of cooling tower model were measured at a fixed swirl ratio (S = 0.54) in the present study. Different radial distances between a cooling tower and stationary tornado vortex center were considered. Translating tornadoes with three different translation speeds (u = 0.04 m/s, 0.12 m/s and 0.2 m/s) were simulated. The results show that a tornado vortex can produce high negative wind pressures on a cooling tower surface due to the negative pressure drop accompanying a tornado. A cooling tower exposed to a tornado experiences combined effects of pressure drop accompanying a tornado and aerodynamic flow-structure interaction.