Review: Multimodal Evaluation of Tissue-Engineered Cartilage

Joseph M. Mansour ； Jean F. Welter

《Journal of Medical and Biological Engineering》 33卷1期 (2013/02) Pp. 1-15

並列摘要

Tissue engineering (TE) has promise as a biological solution and a disease modifying treatment for arthritis. Although cartilage can be generated by TE, substantial inter- and intra-donor variability makes it impossible to guarantee optimal, reproducible results. TE cartilage must be able to perform the functions of native tissue, thus mechanical and biological properties approaching those of native cartilage are likely a prerequisite for successful implantation. A quality-control assessment of these properties should be part of the implantation release criteria for TE cartilage. Release criteria should certify that selected tissue properties have reached certain target ranges, and should be predictive of the likelihood of success of an implant in vivo. Unfortunately, it is not currently known which properties are needed to establish release criteria, nor how close one has to be to the properties of native cartilage to achieve success. Achieving properties approaching those of native cartilage requires a clear understanding of the target properties and reproducible assessment methodology. This paper reviews several main aspects of quality control as it applies to TE cartilage. This includes a look at known mechanical and biological properties of native cartilage, which should be the target for engineered tissues. An overview of the state of the art of tissue assessment, focusing on native articular and TE cartilage, is also presented. Finally, the arguments for developing and validating non-destructive testing methods for assessing TE products are reviewed.

並列關鍵字

Cartilage ； Tissue engineering ； Properties ； Testing