臺灣豬隻全面施打口蹄疫疫苗後之血清中和抗體監測

Surveillance of Serum Neutralization Antibodies to Foot-and-Mouth Disease Virus in Pigs after Intensive Vaccination in Taiwan

廖培志(Pei-Chih Liao) ； 陳世平(Shih-Ping Chen) ； 楊平政(Pin-Cheng Yang) ； 陳靜美(Ching-Mei Chen) ； 鍾明華(Ming-Hwa Jong) ； 許聰文(Tsung-Wen Hsu) ； 鍾文彬(Wen-Bin Chung)

《臺灣獸醫學雜誌》 29卷1期 (2003/03) Pp. 46-52

https://doi.org/10.7009/TVJ.200303.0046

摘要

A planned and scientific surveillance system for foot-and-mouth disease (FMD) was established in this study. A network database system was constructed using Delphi programming language and SQL server database system to effectively store, retrieve, compile and analyze the test results. Four surveillances were carried out starting in June, 2000 (3 years post FMD outbreak) with an interval of 6 months. A total of 14,561 serum samples were collected from 330 pig farms (803 batches) for serological tests. Results showed that the mean serum neutralization (SN) antibody titer (Log10SN50) for finishers increased significantly from 1.45±0.93 to 1.67±0.19 from June, 2000 to November, 2000 (p＜0.05), but significantly decreased to between 1.38 and 1.42 thereafter (p＜0.05). A similar result in sows was also observed. Statistical analysis of test results indicated that the suitable vaccination program for piglets would be vaccinated between the ages of 8 to 12 weeks for the first immunization, followed by a boost 4 weeks later. There was no significant difference between the SN titers of pig vaccinated once at the age of 8 weeks with a high potent vaccine and those of pigs vaccinated twice. Sows vaccinated 3 to 4 weeks before farrowing or once every 4 to 6 months had SN titers between 1.76 and 2.21. The results of this serological surveillance provided the basis for the strategy and decision making in the FMD eradication program and might facilitate the progress of this program.

關鍵字

口蹄疫 ； 豬隻 ； 中和抗體 ； 監測 ； 台灣

並列摘要

A planned and scientific surveillance system for foot-and-mouth disease (FMD) was established in this study. A network database system was constructed using Delphi programming language and SQL server database system to effectively store, retrieve, compile and analyze the test results. Four surveillances were carried out starting in June, 2000 (3 years post FMD outbreak) with an interval of 6 months. A total of 14,561 serum samples were collected from 330 pig farms (803 batches) for serological tests. Results showed that the mean serum neutralization (SN) antibody titer (Log10SN50) for finishers increased significantly from 1.45±0.93 to 1.67±0.19 from June, 2000 to November, 2000 (p＜0.05), but significantly decreased to between 1.38 and 1.42 thereafter (p＜0.05). A similar result in sows was also observed. Statistical analysis of test results indicated that the suitable vaccination program for piglets would be vaccinated between the ages of 8 to 12 weeks for the first immunization, followed by a boost 4 weeks later. There was no significant difference between the SN titers of pig vaccinated once at the age of 8 weeks with a high potent vaccine and those of pigs vaccinated twice. Sows vaccinated 3 to 4 weeks before farrowing or once every 4 to 6 months had SN titers between 1.76 and 2.21. The results of this serological surveillance provided the basis for the strategy and decision making in the FMD eradication program and might facilitate the progress of this program.

並列關鍵字

Foot-and-mouth disease ； Pig ； Serum neutralization antibody ； Surveillance ； Taiwan