- 期刊
Intracerebroventricular Transplantation of Marrow Stromal Cells Promotes Recovery after Spinal Cord Injury in the Rats
並列摘要
Delayed systematic or local administration of bone marrow stromal cells (BMSCs) promotes functional recovery after spinal cord injury. To add therapeutically effective application, we investigated the feasibility of intracerebroventricular administration of BMSCs to repair spinal cord compression injury (SCCI) in the SDrats. Hoechst-labeled BMSCs were immediately microinjected into the fourth ventricle after SCCI. The hindlimb function was significantly improved in injured animals with BMSCs administration compared to the vehicle control as measured by the BBB scoring system. The transplanted BMSCs could migrate and invade into the injured spinal cord, and express certain neural markers. In addition, abundant serotonin-positive axons penetrated into lesion sites of rats with BMSCs transplantation. Data indicate that intracerebroventricular delivery might serve as a mean for transplanting BMSCs into injured spinal cord.
延伸閱讀
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