We herein discuss the stress of a uremic patient who first received hemodialysis treatment based on the Neuman system model and our attempt to help the patient resolve her problems and accept her condition. The duration of nursing care for this patient was from December 23, 2001 to May 31, 2002. The data collection method employed used practical nursing care, interviews with a questionnaire and close observation. After the data was analyzed we found that the present problems of the patient were as follows: 1. a sensation of physical discomfort, 2. adaptation disorder, 3. health-seeking behavior, 4. isolation from society. Guided by the Neuman system model, we provide the primary, secondary and tertiary nursing care to help this patient adapt herself to the hemodialysis treatment, and to ameliorate her physical discomfort caused by uremia. We hope that the patient can establish a correct self-care method, enter social activities with a healthy attitude, and face long-term hemodialysis bravely.