Serogroups and Antimicrobial Susceptibility of Nontyphoidal Salmonella Enterocolitis in Children

兒童非傷寒沙門氏菌感染之血清類型及抗生素敏感性

蕭光宏(Kuang-Hung Hsiao) ； 林隆煌(Lung-Huang Lin) ； 蔡親仁(Chim-Ren Tsai)

《輔仁醫學期刊》 3卷3期 (2005/09) Pp. 143-149

摘要

Background and Purpose: To evaluate the serogroup prevalence, antimicrobial susceptibility, and complications of nontyphoidal salmonellosis in children seen in the past 3 years. Methods: We retrospectively reviewed our pediatric patients younger than 14 years old with proven salmonella enterocolitis from January 2001 to January 2004. The clinical manifestations, laboratory findings, and extraintestinal manifestations of these patients were reviewed. Results: In total, 102 patients were enrolled in this study. The most-common symptoms were diarrhea (98.1%), fever (95.1%), and abdominal pain (91%). All stool cultures grew nontyphoidal salmonella, all of which were sensitive to a third-generation cephalosporin (ceftriaxone). Group B (57.8%) was the most-common salmonella isolate, while the least-common group was serogroup D (16.7%). Nine patients (8.8%) had positive blood culture results for non-typhoidal salmonellosis, but there were no mortalities. Conclusion: Salmonella bacteremia was found in about 9% of patients with non-typhoidal salmonella enterocolitis, and third-generation cephalosporins remain effective. Fever, diarrhea, and abdominal pain were the most-frequent clinical presentations. Our results suggest that children with non-typhoidal salmonellosis with a high CRP, bacteremia, and plain abdominal films showing toxic megacolon may experience an extended hospitalization. However, there was no statistically significant value for leukocytosis, a high CRP value, toxic megacolon, or bacteremia among the 3 serogroups of nontyphoidal salmonella.

關鍵字

兒童 ； 非傷寒沙門氏菌 ； 菌血症

並列摘要

Background and Purpose: To evaluate the serogroup prevalence, antimicrobial susceptibility, and complications of nontyphoidal salmonellosis in children seen in the past 3 years. Methods: We retrospectively reviewed our pediatric patients younger than 14 years old with proven salmonella enterocolitis from January 2001 to January 2004. The clinical manifestations, laboratory findings, and extraintestinal manifestations of these patients were reviewed. Results: In total, 102 patients were enrolled in this study. The most-common symptoms were diarrhea (98.1%), fever (95.1%), and abdominal pain (91%). All stool cultures grew nontyphoidal salmonella, all of which were sensitive to a third-generation cephalosporin (ceftriaxone). Group B (57.8%) was the most-common salmonella isolate, while the least-common group was serogroup D (16.7%). Nine patients (8.8%) had positive blood culture results for non-typhoidal salmonellosis, but there were no mortalities. Conclusion: Salmonella bacteremia was found in about 9% of patients with non-typhoidal salmonella enterocolitis, and third-generation cephalosporins remain effective. Fever, diarrhea, and abdominal pain were the most-frequent clinical presentations. Our results suggest that children with non-typhoidal salmonellosis with a high CRP, bacteremia, and plain abdominal films showing toxic megacolon may experience an extended hospitalization. However, there was no statistically significant value for leukocytosis, a high CRP value, toxic megacolon, or bacteremia among the 3 serogroups of nontyphoidal salmonella.

並列關鍵字

non-typhoidal salmonella ； children ； bacteremia