Colistin治療革蘭氏陰性菌嚴重感染之成效

The Effectiveness of Colistin for the Treatment of Severe Gram-negative Bacteria Infections

胡伯賢(Bor-Shen Hu) ； 吳淑娟(Shu-Chuan Wu)

《北市醫學雜誌》 13卷3期 (2016/09) Pp. 74-87

https://doi.org/10.6200/TCMJ.2016.13.3.09

摘要

目的：本研究旨在分析colistin在某區域醫院之使用情形，評估處方合理性、療效及安全性。方法：本研究採回溯性方式，篩選自2012年1月1日-2014年12月31日之間某區域醫院住院病患開立colistin之處方，制定評估表，評估表分適應症、過程、併發症及治療結果四大指標。結果：本研究期間共收入39位使用colistin治療之患者，符合適應症開立colistin處方佔35.9%，平均用藥天數10±5.2天，產生腎毒性者佔15.4%，粗死亡率41.0%。結論：遵從標準流程來開立colistin之處方，密切監測患者之腎功能，給足建議使用量，降低腎毒性之發生並提高治療成功率，讓民眾能獲得更完善的醫療品質。

關鍵字

Colistin ； 療效

並列摘要

Objective: This study aims to analyse the use of colistin on the rationality, efficacy and safety of prescription in a regional hospital. Methods: The retrospective study collected the prescriptions in a regional hospital from January 1, 2012 to December 31, 2014. The evaluation form which contained was indications, processes, complications, and outcomes were developed. Results: 39 patients were enrolled in this study. The average days of usage was 10 ± 5.2 days ,35.9% of 39 patients meeted the indications of colistin treatments, 15.4% of them had the signs of renal toxicity, and the crude death rate was 41% among these patients. Conclusions: To prescribe the colistin by compling with the standards, to monitor the patients' renal function closely, and the usage of recommended doses can reduce the occurrence of renal toxicity, improve the success rates of treatment and provide better quality of care.

並列關鍵字

Colistin ； efficacy