子宮內膜癌的“三明治”式療法

The "Sandwich" Treatment for High Risk Endometrial Cancer

李耀泰(Yiu-Tai Li) ； 陳福民(Fu-Min Chen) ； 郭宗正(Tsung-Cheng Kuo)

《南臺灣醫學雜誌》 7卷2期 (2011/12) Pp. 123-126

https://doi.org/10.6726/MJST.201112_7(2).0007

摘要

幼早期的子宮內膜癌預後很好，但晚期的患者則治療失敗率很高。因此，對晚期的子宮內膜癌患者，必須積極予術後的輔助治療，即以放射線治療，亦可能合併化學治療。放射線治療可減少骨盆腔病灶的復發，但遠端的病灶須靠化學藥物。現階段，化學藥物以paclitaxel和carboplatin被認為對子宮內膜癌有效，且副作用較少。但以何種方法給予最為理想，根據近期研究，是化學治療－放射線治療－化學治療，即“三明治”式的治療，效果較為理想。

關鍵字

子宮內膜癌 ； 化學治療 ； 放射線治療 ； 三明治式療法

並列摘要

The patients with advanced (stage III, IV) endometrial cancer remain a substantial number with adverse prognostic features who relapse and die of this disease. Recently, the feasibility of administering the combination of chemotherapy and radiotherapy has been reported in the setting of advanced endometrial cancer with the impressive outcome. Sequential therapy consisted of paclitaxel and carboplatin for 3 cycles, followed by pelvic and/or para-aortic radiotherapy and an additional 3 cycles of chemotherapy, this ”sandwich” approach for patients with endometrial cancer has been studied recently. Several authors have reported that treatment modality is associated with a low rate of local recurrence and favorable survival for advanced endometrial cancer.

並列關鍵字

endometrial cancer ； chemotherapy ； radiation ； sandwich method