Evaluation of the Suspending Property of Khaya snegalensis Gum in Co-Trimoxazole Suspensions

The suspending property of Khaya senegalensis (Family Meliaceae) gum in Co-trimoxazole suspension was evaluated. The gum obtained from plants grown in Zaria town of northern Nigeria was processed using standard procedures and its physicochemical properties such as solubility, water sorption, pH and rheology w ere determined. The gum was used to formulate 4.8% w/v co-trimoxazole suspension in concentrations of 0.2-5.0% w/v. Acacia senegal gum was used as a standard for comparison. The sedimentation rates, sedimentation volume, ease of redispersibility and viscosity of the suspension were studied over a period of 8 weeks. Other properties evaluated were drug release profile and particle size distribution of formulated suspensions to detect crystal growth. The results show that the sedimentation rate (4x10^(-4) cm/sec), sedimentation volume (50ml), degree of flocculation (1.52) and viscosity (118.8 m.pas) at 50 r.p.m are values obtained for the suspension containing 0.2%w/v khaya gum after 28 days period of storage. Particle size analysis as an exception, the values of all other parameters obtained for the suspensions containing equivalent concentrations of acacia gum were lower. The suspensions were stable, pourable and redispersible with no evidence of crystal growth. The mean particle size of the drug was 3.5 micrometer. The suspension met the pharmacopoeial requirement for drug release. On the basis of these findings, khaya gum may find application as suspending agent at 0.2%w/v concentrations.

並列關鍵字

Co-Trimoxazole ； crystal growth ； drug release ； khaya senegalensis gum ； sedimentation volume and suspension

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