Stepwise Deterioration of Prothrombin, Factors I, IV but Not Factor XIII in Progressive Stages of Liver Cirrhosis and HCC

Mohamed Hessien ； Mohamed Ayad ； Wafaa M. Ibrahim ； Batoul Izzul Arab

《Asian Journal of Medical Sciences》 2卷1期 (2010/01) Pp. 1-6

並列摘要

This study was designated to investigate the haemostatic changes during the gradual progression of liver diseases. The study included forty patients; thirty of them had liver cirrhosis with different stages (classified according to Childs-Pugh classification) and 10 with hepatocellular carcinoma (HCC). Haemostatic variables including fibrinogen (FI), calcium (FIV), transglutaminase (FXIII), prothrombin time (PT) and platelet count were estimated and compared with the baseline levels of healthy subjects (n=10). The results obtained demonstrated that fibrinogen level progressively decreased and PT prolonged progressively in Child A, C hild B, Child C and reached the maxima in HCC patients. Calcium significantly increased in mild (Child A) and moderate (Child B) but not in Child C cirrhosis and HCC patients, whereas FXIII level did not show any change. Some haemostatic variables were correlated with the hepatic markers albumin and bilirubin but not with aminotransferases. The results of this study indicated that the haemostatic abnormalities in fibrinogen, calcium and PT (but not FXIII) go in parallel to the gradual dysfunction of liver.

並列關鍵字

Child-Pugh classification ； coagulation factors ； fibrinogen ； FIV ； FXIII ； HCC ； liver cirrhosis and PT