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Enhancement of Chronic Intermittent Hypobaric Hypoxia Adaptation on Cardiac Protection of Anandamide in Rats
並列摘要
Anandamide (AEA) has cardiac protective effect and chronic intermittent hypobaric hypoxia (CIHH) adaptation can change the reactivity of the body to some chemicals. We hypothesized that CIHH adaptation could enhance the cardiac protective effect of AEA against ischemia/reperfusion injury. Sprague-Dawley rats were randomly divided into five groups: CIHH for 14 days (CIHH14), CIHH for 28 days (CIHH28), anandamide (AEA), CIHH plus AEA (CIHH+AEA) and control groups. The rats in the CIHH groups were exposed to CIHH for 14 or 28 days, 6 h per day, respectively. The isolated hearts in the AEA rats were treated with 1 nM AEA. The rats in the CIHH+AEA were treated with both CIHH and AEA. Under normal condition, there was no significant in cardiac function among the groups significantly (P ＞ 0.05). In the CIHH+AEA rats, like the CIHH28 rats, the recovery of left ventricular function after ischemia/ reperfusion (30 min global no-flow ischemia followed by 60 min of reperfusion, I/R) was much better than that in the CIHH14 and control rats. Also, LDH in coronary artery effluent was decreased in the CIHH+AEA rats. Compared with the CIHH14, the AEA and control rats, superoxide dismutase (SOD) and malondialdehyde (MDA) in myocardium of the CIHH+AEA rats were increased and decreased after I/R, respectively. The cardiac protective effect in the CIHH+AEA rats was offset by AM630, a CB2 receptor antagonist, but not by AM251, a CB1 receptor antagonist. These data suggest that CIHH adaptation enhances the cardiac protection of AEA through activation of CB2 receptor and increase of anti-oxidation in the myocardium of rats.
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