以kinetics-based enzyme-linked immunosorbent assay及immunoblotting偵測臺北市貓及人之弓蟲IgG與IgM抗體盛行率。街貓(37.0%, n=100)比家貓(14.0%, n=57)有顯著高的抗體盛行率。同時,街貓有比家貓高的IgG geometric mean titer(GMT)(1:393 vs 1:22),但兩者有相似的IgM GMT(1:23 vs 1:20)。街貓之中,雌性(50.0%)比雄性(24.0%)有顯著高的抗體盛行率。家貓之比較,乃利用-logistic regression model分析五種因子(性別,年齡,重量,品種,活動領域)。結果發現,當家貓逐漸年老,其抗體陽性之odds ratio也跟著升高。然而,抗體盛行率和性別,重量,品種,及室內外活動領域無關。在人類,IgG抗體盛行率為7.0%(n=100),其GMT為1:77,和性別無關。獸醫師之弓蟲抗體盛行率並沒比護士高。
The prevalences of IgG and IgM antibodies to Toxoplasma gondii in cats and humans in Taipei, Taiwan were measured by using both kinetics-based enzyme-linked immunosorbent assay and immunoblotting. Stray cats had significantly higher seroprevalence (37.0%, n=100) than pet cats (14.0%, n=57). Also, stray cats had higher IgG (1:393 vs 1:22), but similar IgM (1:23 vs 1:20) geometric mean titers (GMT) compared to the pet cats. Stray female cats had a significantly higher seroprevalence (50.0%) than males (24.0%). For the comparisons of the pet animals, a logistic regression model with five factors (sex, age, weight, breed, domain) was analyzed In pet cats, as the animals were growing older the odds ratio for them to be seropositive was getting higher. However, seroprevalence was not sex-, weight-, breed-, or indoor/outdoor activity-dependent. In humans, the prevalence of IgG antibody (which was not sex-dependent) was 7.0% (n=100) and the GMT was 1:177. Veterinarians did not have higher seroprevalence than that or nurses.
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