Primary hepatic liposarcoma is extremely rare and only a few cases have been reported in the English literature. Here, we report a case of myxoid-type primary hepatic liposarcoma in a 63-year-old man presenting with low back pain. Before surgery, dynamic abdominal computed tomography (CT) revealed a well-marginated mass in the left lobe of the liver with a fat component. There was no enhancement of the fat component and only mild delayed enhancement of the soft-tissue component after the administration of contrast. The pathological diagnosis was a myxoid liposarcoma of liver. The patient was doing well a t least five years after a left segmentectomy of the liver A CT study was used preoperatively in the diagnosis of a hepatic liposarcoma and was helpful in differentiating the liposarcoma from other fat-containing tumors.