After years of continuous development, Vietnam is now facing the congestion of traffic and the inefficiency of the transportation system that exert a great pressure on the economic development. The government is planning a Vietnam High Speed Rail (VHSR) project to connect its long-shape country from Hanoi to Hochiminh city. The Nha Trang – Ho Chi Minh City route is the individual southern part of the VHSR project. The government is now facing the difficulty of getting enough money to finance for this project. Public objection to the future financial burden is also an obstacle that could make the project unfeasible. The BOT approach is emerging as a very powerful project-financing scheme in the world today. By reviewing vital conditions that the Vietnamese government and the private sector have had for the BOT application, this study presents the feasibility of BOT application to the VHSR project: the Nhatrang to Hochiminh city route. Finally, based on the performance of the BOT projects in Vietnam, experiences of the Taiwan High-speed Rail project and BOT experiences in the world, the study also suggests recommendations to improve efficiency of BOT application in this project.