配對病例對照鑑取抽樣下家族聚集性的研究

Familial aggregation studies with matched case-control proband sampling

林蕙敏(Hui-Min Lin)

指導教授 ： 陳麗菁

淡江大學/管理學院/統計學系碩士班/碩士(2007年)

https://doi.org/10.6846/TKU.2007.00115

摘要

本文考慮以配對病例對照鑑取抽樣 (matched case-control proband sampling) 來探討疾病的「家族聚集性 (familial aggregation) 」現象。當沒有共變量資訊時，我們推廣 Datta & Satten (2005) 群集資料的秩和檢定 (rank-sum test for clustered data)，以無母數統計法檢視疾病是否存在家族聚集性。當進一步蒐集到共變量資料時,我們推廣 Liang & Pulver (1996) 的方法，透過模型的建立，以解析家族聚集性的起因：遺傳因素或是環境因素。針對推廣後的新方法，我們亦進行有限樣本的模擬研究。最後就阻塞型睡眠呼吸中止症候群 (Obstructive sleep apnea, OSA) 的虛擬資料進行實例分析。

關鍵字

家族聚集性 ； 配對病例對照鑑取抽樣 ； 秩和檢定 ； 廣義估計方程式

並列摘要

In this paper, some methods are proposed for the analysis of matched case-control proband data arising from familial aggregation studies. When there is no covariate information, we generalized the rank-sum test for clustered data (Datta & Satten, 2005) to detect
familial aggregation. If there are some cavariate informations, we apply the generalized method of Liang & Pulver (1996) to analyze the cause of familial aggregation : genetic or environmental factors. We apply the proposed methods to obstructive sleep apnea pseudodata.
Some simulation studies with finite sample demonstrate the usefulness of our approach.

並列關鍵字

familial aggregation ； generalized estimating equation ； matched case-control proband sampling ； rank-sum test

參考文獻

1. Agresti, A. (2002), Categorical Data Analyasis, 2nd. New York: John Wiley.

2. Breslow, N.E. (1996), Statistics in Epidemiology: The Case-Control Study. Journal of the American Statistical Association, 91, 14-28.

4. Datta, S., and Satten, G.A. (2005), Rank-sum tests for clustered data. Journal of the American Statistical Association, 100, 908-915.

5. Liang, K.Y., and Beaty, T.H. (2000), Statistical designs for familial aggregation. Statistical Methods in Medical Research, 9, 543-562.

6. Liang, K.Y., and Pulver, A.E. (1996), Analysis of case-control/family sampling design. Genetic Epidemiology, 13, 253-270.